In vitro release of nitroglycerin from topical products by use of artificial membranes.

@article{Wu1992InVR,
  title={In vitro release of nitroglycerin from topical products by use of artificial membranes.},
  author={Spencer T. Wu and Gerald K. Shiu and John E. Simmons and Robert L. Bronaugh and Jerome Philip Skelly},
  journal={Journal of pharmaceutical sciences},
  year={1992},
  volume={81 12},
  pages={1153-6}
}
An in vitro testing method for measuring the release of nitroglycerin from topical drug products was evaluated. The method involved measuring the amount of nitroglycerin that diffused from ointments and patches through various synthetic membranes into receptor fluid contained in a modified Franz diffusion cell. Plots of the amount of nitroglycerin released against the square root of time for all 10 synthetic membranes were linear. Five membranes (group I) were found to release nitroglycerin at… CONTINUE READING