In vitro release of heparin from silica xerogels.

@article{Ahola2001InVR,
  title={In vitro release of heparin from silica xerogels.},
  author={Manja Ahola and Eija Sinikka S{\"a}ilynoja and M H Raitavuo and Minna Vaahtio and Jukka I. Salonen and Antti Yli-Urpo},
  journal={Biomaterials},
  year={2001},
  volume={22 15},
  pages={
          2163-70
        }
}
Heparin, a powerful anticoagulant used for the prophylaxis of both surgical and medical thrombosis, was incorporated into a silica xerogel matrix during polycondensation of organic silicate. The influence of various chemical sol-gel parameters (the properties of reaction precursors, catalyst and final moisture content of the gel and heparin concentration) was studied. The release of heparin from the gel was according to zero order during the dissolution period and the release rate of heparin… CONTINUE READING
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