In vitro release of antibiotics from commercial PMMA beads and articulating hip spacers.

@article{Moojen2008InVR,
  title={In vitro release of antibiotics from commercial PMMA beads and articulating hip spacers.},
  author={Dirk Jan F. Moojen and Bram Hentenaar and H Charles Vogely and Abraham J. Verbout and Ren{\'e} M. Castelein and Wouter J. A. Dhert},
  journal={The Journal of arthroplasty},
  year={2008},
  volume={23 8},
  pages={1152-6}
}
The efficacy and benefits of high-dose antibiotic cement spacers compared with beads in the treatment of an infected prosthesis have been shown. However, in clinical practice, commercial, low-dose antibiotic bone cement is often used. This study investigated the in vitro antibiotic release of hip spacers made from Refobacin-Palacos-R or Antibiotic-Simplex-P cement compared with Septopal beads. Antibiotic concentrations were measured during 6 weeks. All carriers showed a burst release, but… CONTINUE READING

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