In vitro release and biosynthesis of tumor ACTH in ectopic ACTH producing tumors.

@article{Hirata1975InVR,
  title={In vitro release and biosynthesis of tumor ACTH in ectopic ACTH producing tumors.},
  author={Yukio Hirata and Hideki Yamamoto and Shigeru Matsukura and Hiroo Imura},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1975},
  volume={41 1},
  pages={106-14}
}
Tumor tissues obtained from 4 patients with the ectopic ACTH syndrome were studied for release and synthesis of tumor ACTH, using an in vitro incubation system. The effect of various agents on release of tumor ACTH was evaluated in three cases; beta-MSH released and adenosine 3',5'-monophosphate (cyclic AMP) formed in the tissue were determined in one. Biosynthetic experiments using labeled amino acid incorporation were performed in two cases. Secretion of tumor ACTH was significantly… CONTINUE READING