Corpus ID: 18925234

In vitro reconstitution of calreticulin-substrate interactions.

@article{Peterson1999InVR,
  title={In vitro reconstitution of calreticulin-substrate interactions.},
  author={J. R. Peterson and A. Helenius},
  journal={Journal of cell science},
  year={1999},
  volume={112 ( Pt 16)},
  pages={
          2775-84
        }
}
  • J. R. Peterson, A. Helenius
  • Published 1999
  • Biology, Medicine
  • Journal of cell science
  • Calreticulin is a soluble, endoplasmic reticulum-resident protein and a molecular chaperone for glycoproteins. We have reconstituted the binding of recombinant calreticulin to two glycoprotein substrates, vesicular stomatitis virus G protein and influenza hemagglutinin, in vitro. The binding was found to be direct and to require monoglucosylated, asparagine-linked oligosaccharides on the substrate glycoprotein but no other cellular factors. The binding could be modulated in vitro by incubation… CONTINUE READING
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