In vitro reconstitution of Bluetongue virus infectious cores.

  title={In vitro reconstitution of Bluetongue virus infectious cores.},
  author={Sofia Da Silva Lourenco and Polly Roy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 33},
Bluetongue virus (BTV) is a vector-borne, nonenveloped icosahedral particle that is organized in two capsids, an outer capsid of two proteins, VP2 and VP5, and an inner capsid (or core) composed of two major proteins, VP7 and VP3, in two layers. The VP3 layer (subcore) encloses viral transcription complex (VP1 polymerase, VP4 capping enzyme, VP6 helicase) and a 10-segmented double-stranded (dsRNA) genome. Although much is known about the BTV capsids, the order of the core assembly and the… CONTINUE READING