In vitro reconstitution and substrate specificity of a lantibiotic protease.

@article{Ihnken2008InVR,
  title={In vitro reconstitution and substrate specificity of a lantibiotic protease.},
  author={L A Furgerson Ihnken and Champak Chatterjee and Wilfred A van der Donk},
  journal={Biochemistry},
  year={2008},
  volume={47 28},
  pages={7352-63}
}
Lacticin 481 is a lanthionine-containing bacteriocin (lantibiotic) produced by Lactococcus lactis subsp. lactis. The final steps of lacticin 481 biosynthesis are proteolytic removal of an N-terminal leader sequence from the prepeptide LctA and export of the mature lantibiotic. Both proteolysis and secretion are performed by the dedicated ATP-binding cassette (ABC) transporter LctT. LctT belongs to the family of AMS (ABC transporter maturation and secretion) proteins whose prepeptide substrates… CONTINUE READING
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