In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs

@article{Butterweck2002InVR,
  title={In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs},
  author={Veronika Butterweck and Adolf Nahrstedt and Jon Evans and Sandy J Hufeisen and Laura Rauser and Jason Savage and Beth A Popadak and Paul R Ernsberger and Bryan L. Roth},
  journal={Psychopharmacology},
  year={2002},
  volume={162},
  pages={193-202}
}
Abstract Rationale. Hypericum perforatum L. (St. John's wort; SJW) is one of the leading psychotherapeutic phytomedicines and great effort has been devoted to clarifying its mechanism of action. Objective. We have undertaken a comprehensive analysis of several pure compounds isolated from the crude extract to gain further insight into the molecular actions of various substituents of SJW. Methods. We characterized the in vitro pharmacology of the naphthodianthrones hypericin and pseudohypericin… CONTINUE READING
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