In vitro receptor binding properties of a "painless" NGF mutein, linked to hereditary sensory autonomic neuropathy type V.

@article{Covaceuszach2010InVR,
  title={In vitro receptor binding properties of a "painless" NGF mutein, linked to hereditary sensory autonomic neuropathy type V.},
  author={Sonia Covaceuszach and Simona Capsoni and Sara Marinelli and Flaminia Pavone and Marcello Ceci and Gabriele Ugolini and Domenico Vignone and Gianluca Amato and Francesca Paoletti and Doriano Lamba and Antonino Cattaneo},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={391 1},
  pages={
          824-9
        }
}
Nerve Growth Factor (NGF) signalling is mediated by the TrkA and p75NTR receptors. Besides its neurotrophic and survival activities, NGF displays a potent pro-nociceptive activity. Recently, a missense point mutation was found in the NGFB gene (C661T, leading to the aminoacid substitution R100W) of individuals affected by a form of hereditary loss of pain perception (hereditary sensory and autonomic neuropathy type V, HSAN V). In order to gain insights into the functional consequences of the… CONTINUE READING
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