In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure.

@article{Besaratinia2009InVR,
  title={In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure.},
  author={Ahmad Besaratinia and Sang-in Kim and Pierre Hainaut and Gerd. P. Pfeifer},
  journal={Gastroenterology},
  year={2009},
  volume={137 3},
  pages={1127-37, 1137.e1-5}
}
BACKGROUND & AIMS Dietary exposure to aflatoxin B(1) (AFB(1)), in addition to other known factors, increases risk for human hepatocellular carcinoma (HCC). HCCs from AFB(1)-exposed individuals frequently have distinct TP53 mutations, such as G to T transversions in the second guanine of codon 249 (AGG to AGT), and a characteristic mutational spectrum predominated by G:C to T:A mutations. METHODS To recapitulate the distinctive features of TP53 mutations in AFB(1)-associated HCC, we… CONTINUE READING
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