In vitro reactivation of anaphase spindle elongation using isolated diatom spindles

@article{Cande1985InVR,
  title={In vitro reactivation of anaphase spindle elongation using isolated diatom spindles},
  author={William Zacheus Cande and Kent L. McDonald},
  journal={Nature},
  year={1985},
  volume={316},
  pages={168-170}
}
A key step for analysing the mechanochemistry of mitosis would be the isolation of a functional spindle capable of anaphase chromosome movement in vitro. Although Mazia and Dan first isolated spindles in 19521, with one or two possible exceptions2–4, isolated spindles are non-functional (reviewed in ref. 5). An alternative approach has used permeabilized cells to study anaphase chromosome movement6–10, but these preparations are biochemically and morphologically complex, and hence difficult to… CONTINUE READING
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