In vitro reactions of glycidol with pyrimidine bases in calf thymus DNA.

Abstract

The 3-carbon epoxide glycidol (GLC) was reacted with dCyd and dThd at pH 7.0 to 7.5 and 37 degrees C for 10 h. The only product detected from the reaction with dCyd was 3-(2,3-dihydroxypropyl)-dUrd (3-DHP-dUrd) whose structure was established from UV spectra, isobutane chemical ionization (CI) mass spectra together with accurate mass measurements and… (More)

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Cite this paper

@article{Segal1990InVR, title={In vitro reactions of glycidol with pyrimidine bases in calf thymus DNA.}, author={A. Segal and Joshua Solomon and Frank H. Mukai}, journal={Cancer biochemistry biophysics}, year={1990}, volume={11 1}, pages={59-67} }