Corpus ID: 24138566

In vitro reaction of beta-propiolactone and gamma-butyrolactone with glutathione and cysteine.

@article{Dijkstra1975InVR,
  title={In vitro reaction of beta-propiolactone and gamma-butyrolactone with glutathione and cysteine.},
  author={J. Dijkstra},
  journal={Chemico-biological interactions},
  year={1975},
  volume={10 2},
  pages={
          115-21
        }
}
  • J. Dijkstra
  • Published 1975
  • Medicine
  • Chemico-biological interactions
The in vitro reaction of the carcinogenic beta-propiolactone (BPL) and the non-carcinogenic gamma-butyrolactone (GBL) with glutathione (GSH) and cysteine (CySH) was examined spectrophotometrically. The characteristic absorbance of thioesters in the region of 233 nm appeared when BPL and GSH reacted but not when BPL and CySH reacted or when GBL was mixed with GSH or CySH. The absorbance disappeared when hydroxylamine was added. The results are in striking contrast to the notion that all… Expand
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