In vitro radiosensitizing effects of ultrasmall gadolinium based particles on tumour cells.

@article{Mowat2011InVR,
  title={In vitro radiosensitizing effects of ultrasmall gadolinium based particles on tumour cells.},
  author={Pierre Mowat and Anna Mignot and Wael Rima and François Lux and Olivier Tillement and Christophe Roulin and Marie Dutreix and Denise Bechet and Sandrine Huger and Laure Humbert and Muriel Barberi-Heyob and M T Aloy and Emma Armandy and Claire Rodriguez-Lafrasse and G{\'e}raldine Le Duc and St{\'e}phane Roux and Pascal Perriat},
  journal={Journal of nanoscience and nanotechnology},
  year={2011},
  volume={11 9},
  pages={7833-9}
}
Since radiotherapy is widely used in cancer treatment, it is essential to develop strategies which lower the irradiation burden while increasing efficacy and become efficient even in radio resistant tumors. Our new strategy is relying on the development of solid hybrid nanoparticles based on rare-earth such as gadolinium. In this paper, we then evidenced that gadolinium-based particles can be designed to enter efficiently into the human glioblastoma cell line U87 in quantities that can be tuned… CONTINUE READING

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