In vitro proteolytic processing of the MD145 norovirus ORF1 nonstructural polyprotein yields stable precursors and products similar to those detected in calicivirus-infected cells.

@article{Belliot2003InVP,
  title={In vitro proteolytic processing of the MD145 norovirus ORF1 nonstructural polyprotein yields stable precursors and products similar to those detected in calicivirus-infected cells.},
  author={Ga{\"e}l Belliot and Stanislav V. Sosnovtsev and Tanaji Mitra and Carl Hammer and Mark K Garfield and Kim Y Green},
  journal={Journal of virology},
  year={2003},
  volume={77 20},
  pages={
          10957-74
        }
}
The MD145-12 strain (GII/4) is a member of the genus Norovirus in the Caliciviridae and was detected in a patient with acute gastroenteritis in a Maryland nursing home. The open reading frame 1 (ORF1) (encoding the nonstructural polyprotein) was cloned as a consensus sequence into various expression vectors, and a proteolytic cleavage map was determined. The virus-encoded cysteine proteinase mediated at least five cleavages (Q(330)/G(331), Q(696)/G(697), E(875)/G(876), E(1008)/A(1009), and E… CONTINUE READING

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