In vitro progression of human papillomavirus 16 episome-associated cervical neoplasia displays fundamental similarities to integrant-associated carcinogenesis.

@article{Gray2010InVP,
  title={In vitro progression of human papillomavirus 16 episome-associated cervical neoplasia displays fundamental similarities to integrant-associated carcinogenesis.},
  author={Elizabeth Gray and Mark R. Pett and Dawn M Ward and David M. Winder and Margaret Stanley and Ian W. Roberts and Cinzia G. Scarpini and Nicholas Coleman},
  journal={Cancer research},
  year={2010},
  volume={70 10},
  pages={4081-91}
}
An important event in the development of cervical squamous cell carcinoma (SCC) is deregulated expression of high-risk human papillomavirus (HR-HPV) oncogenes, most commonly related to viral integration into host DNA. Mechanisms of development of the approximately 15% of SCCs that contain extrachromosomal (episomal) HR-HPV are poorly understood due to limited longitudinal data. We therefore used the W12 model to study mechanisms of cervical carcinogenesis associated with episomal HPV16. In… CONTINUE READING
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Selection of cervical keratinocytes containing integrated HPV16 associates with Cancer

  • MR Pett, MT Herdman, RD Palmer
  • Research h
  • 2010
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