In vitro progesterone modulation on bacterial endotoxin-induced production of IL-1β, TNFα, IL-6, IL-8, IL-10, MIP-1α, and MMP-9 in pre-labor human term placenta

@article{GarcaRuiz2015InVP,
  title={In vitro progesterone modulation on bacterial endotoxin-induced production of IL-1β, TNFα, IL-6, IL-8, IL-10, MIP-1α, and MMP-9 in pre-labor human term placenta},
  author={G. Garc{\'i}a-Ruiz and P. Flores-Espinosa and E. Preciado-Mart{\'i}nez and L. Bermejo-Mart{\'i}nez and A. Espejel-N{\'u}{\~n}ez and G. Estrada-Guti{\'e}rrez and R. Maida-Claros and A. Flores-Pliego and V. Zaga-Clavellina},
  journal={Reproductive Biology and Endocrinology : RB&E},
  year={2015},
  volume={13}
}
  • G. García-Ruiz, P. Flores-Espinosa, +6 authors V. Zaga-Clavellina
  • Published 2015
  • Medicine, Biology
  • Reproductive Biology and Endocrinology : RB&E
  • BackgroundDuring human pregnancy, infection/inflammation represents an important factor that increases the risk of developing preterm labor. The purpose of this study was to determine if pre-treatment with progesterone has an immunomodulatory effect on human placenta production of endotoxin-induced inflammation and degradation of extracellular matrix markers.MethodsPlacentas were obtained under sterile conditions from pregnancies delivered at term before the onset of labor by cesarean section… CONTINUE READING
    Zika-virus-infected human full-term placental explants display pro-inflammatory responses and undergo apoptosis
    • 7
    • Open Access

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