In vitro production and subsequent transplantation of a living skin substitute in rat model

@article{Ross1992InVP,
  title={In vitro production and subsequent transplantation of a living skin substitute in rat model},
  author={U. H. Ross},
  journal={European Archives of Oto-Rhino-Laryngology},
  year={1992},
  volume={249},
  pages={263-267}
}
Three different transplants were generated for in vitro production of a living skin substitute in a rat animal model. In all cases epithelial cells from a small skin biopsy were grown in cell culture. Compound 1 consisted of cells outgrowing on lyophilized human dura mater. Compound 2 was fabricated with lyophilized porcine dermis. In compound 3 a lamella of dehydrated human fascia lata was seeded with epidermal cells. These skin substitutes were used to cover full-thickness skin defects. The… CONTINUE READING