In vitro priming to direct neuronal fate in adult neural progenitor cells.

@article{Vazey2009InVP,
  title={In vitro priming to direct neuronal fate in adult neural progenitor cells.},
  author={Elena M. Vazey and Bronwen Connor},
  journal={Experimental neurology},
  year={2009},
  volume={216 2},
  pages={520-4}
}
We have previously reported methods that allow for the routine isolation, culture and transplantation of multipotent neural progenitor cells (NPCs) derived from the adult rat sub-ventricular zone (SVZ). In order to expand these techniques, the aim of the current study was to develop an in vitro strategy which can "prime" proliferating adult NPCs towards a neuronal fate during their subsequent differentiation under standard conditions. Our results show that transient exposure to lithium chloride… CONTINUE READING

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