In vitro primary sensitization and restimulation of hapten-specific T cells by fresh and cultured human epidermal Langerhans' cells.

@article{Moulon1993InVP,
  title={In vitro primary sensitization and restimulation of hapten-specific T cells by fresh and cultured human epidermal Langerhans' cells.},
  author={Corinne Moulon and Josette P{\'e}guet-Navarro and Pascal Courtellemont and G Redziniak and Daniel R Schmitt},
  journal={Immunology},
  year={1993},
  volume={80 3},
  pages={373-9}
}
We examined the capacity of human Langerhans's cells (LC) to sensitize autologous T cells to the trinitrophenyl hapten (TNP) in vitro. Two-day cultured Langerhans' cells, but not freshly prepared Langerhans' cells, can induce in vitro primary proliferative reactions to the TNP hapten. Using a CD45RA+ naive T-cell subset, similar results were found, therefore making the possibility of a previous in vivo T-cell contact with the hapten unlikely. The primary in vitro response was strongly inhibited… CONTINUE READING

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