Corpus ID: 37260104

In vitro potential measurement, anaesthetic and antimicrobial effects as indicators of beta-blocker toxicity of the cornea.

@article{Himber1985InVP,
  title={In vitro potential measurement, anaesthetic and antimicrobial effects as indicators of beta-blocker toxicity of the cornea.},
  author={J. Himber and G. Andermann and M. Erhart and G. Leclerc and M. Bouzoubaa},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1985},
  volume={7 4},
  pages={
          195-201
        }
}
Three tests were utilized to determine and compare the toxicity of timolol, propranolol and two new aliphatic and alicyclic oxime ethers with beta-blocking activity (falintolol and compound POS 7). Effects on the electrical potential difference across the in vitro bovine corneal epithelium. Local anaesthesia on in vivo rabbit cornea. Antimicrobial activity on bacterial and fungal suspensions. In addition, partition coefficients were determined as physicochemical properties of the drugs… Expand
5 Citations
Ocular toxicity of some corneal penetration enhancers evaluated by electrophysiology measurements on isolated rabbit corneas.
Cyclic AMP modulation of active ion transport in the pigmented rabbit conjunctiva.
  • U. Kompella, K. Kim, M. Shiue, V. Lee
  • Chemistry, Medicine
  • Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
  • 1996
Treatment of infectious disease: beyond antibiotics.