In vitro postantibiotic effect of daptomycin (LY146032) against Enterococcus faecalis and methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains.

@article{Bush1989InVP,
  title={In vitro postantibiotic effect of daptomycin (LY146032) against Enterococcus faecalis and methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains.},
  author={Larry M. Bush and Jerome A. Boscia and Michael Wendeler and Peter G. Pitsakis and Donald Kaye},
  journal={Antimicrobial agents and chemotherapy},
  year={1989},
  volume={33 8},
  pages={
          1198-200
        }
}
The suppression of bacterial growth that persists after brief exposure to antimicrobial agents has been termed the postantibiotic effect (PAE). This pharmacodynamic interaction varies for each microorganism-antimicrobial agent combination. Daptomycin (LY146032) is a new lipopeptide antibiotic with activity against gram-positive organisms. We studied the in vitro bactericidal activities and PAEs of the following drugs: daptomycin compared with penicillin G and vancomycin, without and with… CONTINUE READING

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