In vitro platination of human breast cancer suppressor gene1 (BRCA1) by the anticancer drug carboplatin.

@article{Ratanaphan2005InVP,
  title={In vitro platination of human breast cancer suppressor gene1 (BRCA1) by the anticancer drug carboplatin.},
  author={Adisorn Ratanaphan and Bhutorn Canyuk and Siriwat Wasiksiri and Pawika Mahasawat},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1725 2},
  pages={
          145-51
        }
}
Carboplatin is an anticancer drug for the treatment of cancers affecting various organs including ovary and testes. It essentially exerts its cytotoxicity against cancerous cells via covalent attachment of platinum atom to DNA, generating various platinum-DNA adducts. Platinum-DNA adducts inhibit biological processes essential for cellular viability. However, carboplatin interacts nonspecifically with DNA, resulting in damaging of normal cell DNA. Potential in vitro interaction of carboplatin… CONTINUE READING

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