In vitro platelet aggregation defects in patients with myeloproliferative disorders and high platelet counts: are they laboratory artefacts?

@article{Grignani2009InVP,
  title={In vitro platelet aggregation defects in patients with myeloproliferative disorders and high platelet counts: are they laboratory artefacts?},
  author={Claudio Grignani and Patrizia Noris and Carmine Tinelli and Giovanni Barosi and Carlo Luigi Balduini},
  journal={Platelets},
  year={2009},
  volume={20 2},
  pages={131-4}
}
It has been recently shown that in vitro platelet aggregation is inhibited when platelet concentration in platelet-rich plasma (PRP) is "normalized" by the addition of platelet-poor plasma (PPP). In this study we tested the hypothesis that the large amount of PPP required to "normalize" PRP in patients with thrombocytosis may result in falsely defective… CONTINUE READING