In vitro physiologically based extraction test (PBET) and bioaccessibility of arsenic and lead from various mine waste materials.

@article{Bruce2007InVP,
  title={In vitro physiologically based extraction test (PBET) and bioaccessibility of arsenic and lead from various mine waste materials.},
  author={Scott Bruce and Barry Noller and Vitukawalu P Matanitobua and Jack Ng},
  journal={Journal of toxicology and environmental health. Part A},
  year={2007},
  volume={70 19},
  pages={1700-11}
}
In vivo models show that the bioavailability of soil contaminants varies between site and type of matrix. Studies demonstrated that assuming 100% bioavailability of arsenic (As) and lead (Pb) from soils and mine waste materials overestimates the risk associated with human exposure. In in vitro systems, the simulated bioavailability of a contaminant is referred to as the "bioaccessibility" and is used as an alternative quantitative indicator for in vivo derived bioavailability estimates. The… CONTINUE READING

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