In vitro photoperoxidation as an indicator of the potential phototoxicity of non-steroidal anti-inflammatory 2-arylpropionic acids.

Abstract

The photochemical behaviour of 2-arylpropionic acids involves the intermediacy of short-lived species such as drug-derived peroxides and/or free radicals. Although peroxides are expected to undergo very rapid breakdown, this study shows that they can be detected in the photomixtures by the peroxidase-catalysed oxidation of dichlorodihydrofluorescein to its… (More)

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