In vitro photodynamic activity of a series of methylene blue analogues.

@article{Mellish2002InVP,
  title={In vitro photodynamic activity of a series of methylene blue analogues.},
  author={Kirste J Mellish and Russell D. Cox and David I Vernon and John Griffiths and Stanley B Brown},
  journal={Photochemistry and photobiology},
  year={2002},
  volume={75 4},
  pages={392-7}
}
We have synthesized a series of symmetrical phenothiazines in which the methyl groups of methylene blue have been substituted by longer alkyl chains. Intrinsic photosensitizing ability was not altered by increasing the chain length. However, in vitro phototoxicity after 2 h incubation of RIF-1 murine fibrosarcoma cells followed the order n-propyl > n-pentyl > n-butyl > n-hexyl > ethyl > methyl, with ethyl and n-propyl analogues being 14- and 130-fold more phototoxic than methylene blue… CONTINUE READING

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