In vitro phase I cytochrome P450 metabolism, permeability and pharmacokinetics of SB639, a novel histone deacetylase inhibitor in preclinical species.

@article{Venkatesh2007InVP,
  title={In vitro phase I cytochrome P450 metabolism, permeability and pharmacokinetics of SB639, a novel histone deacetylase inhibitor in preclinical species.},
  author={Pilla Reddy Venkatesh and Evelyn Goh and Peizi Zeng and Lee Sun New and Liu Jian Xin and Mohammed Khalid Pasha and Kanda Sangthongpitag and Pauline Yeo and Ethirajulu Kantharaj},
  journal={Biological & pharmaceutical bulletin},
  year={2007},
  volume={30 5},
  pages={1021-4}
}
In vitro liver microsomal stability, permeability, pharmacokinetics (PK) and oral bioavailability of SB639, a novel HDACi (Histone Deacetylase inhibitor), were determined. The in vitro metabolism was examined in mouse, rat, dog and human liver microsomes. The permeability and efflux potential of SB639 were determined using Caco-2 cell monolayers. To determine pharmacokinetics and oral bioavailability, blood samples were drawn at pre-determined intervals up to 24 h post-dose after single… CONTINUE READING

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