In vitro pharmacology of clinically used central nervous system-active drugs as inverse H(1) receptor agonists.

@article{Bakker2007InVP,
  title={In vitro pharmacology of clinically used central nervous system-active drugs as inverse H(1) receptor agonists.},
  author={Remko A. Bakker and Matilda W. Nicholas and Tracy T Smith and Ethan S. Burstein and Uli Hacksell and Henk Timmerman and Rob Leurs and Mark R. Brann and Dave M Weiner},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={322 1},
  pages={172-9}
}
The human histamine H(1) receptor (H(1)R) is a prototypical G protein-coupled receptor and an important, well characterized target for the development of antagonists to treat allergic conditions. Many neuropsychiatric drugs are also known to potently antagonize this receptor, underlying aspects of their side effect profiles. We have used the cell-based receptor selection and amplification technology assay to further define the clinical pharmacology of the human H(1)R by evaluating >130… CONTINUE READING