In vitro pharmacologic characterization of a cholinergic receptor on outer hair cells.

@article{Erostegui1994InVP,
  title={In vitro pharmacologic characterization of a cholinergic receptor on outer hair cells.},
  author={Carlos Erostegui and C. H. Norris and Richard P. Bobbin},
  journal={Hearing research},
  year={1994},
  volume={74 1-2},
  pages={135-47}
}
Acetylcholine (ACh) is the major neurotransmitter released from the efferent fibers in the cochlea onto the outer hair cells (OHCs). The type of ACh receptor on OHCs and the events subsequent to receptor activation are unclear. Therefore we studied the effect of agonists and antagonists of the ACh receptor on isolated OHCs from the guinea pig. OHCs were recorded from in whole cell voltage and current clamp configuration. ACh induced an increase in outward K+ current (IACh) which hyperpolarized… CONTINUE READING