In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator.

@article{Adams1989InVP,
  title={In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator.},
  author={David J Adams},
  journal={Cancer research},
  year={1989},
  volume={49 23},
  pages={6615-20}
}
A microtiter pharmacodynamic assay is described that evaluates antitumor activity in vitro within a matrix of extracellular drug concentrations (C) and exposure times (T). The results were analyzed according to the pharmacodynamic principle: Cn x T = k, where n is the concentration coefficient and k is the drug exposure constant. This assay was used to characterize the antitumor activity of crisnatol (BW A770U), a member of the new arylmethylaminopropanediol class of DNA intercalators, in MCF-7… CONTINUE READING

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