In vitro ozone exposure increases release of arachidonic acid products from a human bronchial epithelial cell line.

@article{McKinnon1993InVO,
  title={In vitro ozone exposure increases release of arachidonic acid products from a human bronchial epithelial cell line.},
  author={Karen P McKinnon and Michael C. Madden and Terry L Noah and Robert B. Devlin},
  journal={Toxicology and applied pharmacology},
  year={1993},
  volume={118 2},
  pages={
          215-23
        }
}
Eicosanoids released after ozone exposure of a human bronchial epithelial cell line, BEAS-S6, were analyzed by high-pressure liquid chromatography (HPLC) of supernatants from exposed cells prelabeled with [3H]arachidonic acid. BEAS cells released thromboxane B2 (TxB2), prostaglandin E2 (PGE2), leukotriene C4 (LTC4), LTD4, LTE4, and 12-hydroxyheptadecatrienoic acid (HHT) after exposure to ozone at concentrations of 0.1, 0.25, 0.5, and 1.0 ppm. The eicosanoids were identified by coelution with… Expand
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