In vitro ozone exposure increases release of arachidonic acid products from a human bronchial epithelial cell line.

  title={In vitro ozone exposure increases release of arachidonic acid products from a human bronchial epithelial cell line.},
  author={Karen P McKinnon and Michael C. Madden and Terry L Noah and Robert B. Devlin},
  journal={Toxicology and applied pharmacology},
  volume={118 2},
Eicosanoids released after ozone exposure of a human bronchial epithelial cell line, BEAS-S6, were analyzed by high-pressure liquid chromatography (HPLC) of supernatants from exposed cells prelabeled with [3H]arachidonic acid. BEAS cells released thromboxane B2 (TxB2), prostaglandin E2 (PGE2), leukotriene C4 (LTC4), LTD4, LTE4, and 12-hydroxyheptadecatrienoic acid (HHT) after exposure to ozone at concentrations of 0.1, 0.25, 0.5, and 1.0 ppm. The eicosanoids were identified by coelution with… Expand
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Increased 5-lipoxygenase metabolism in the lungs of human subjects exposed to ozone.
The environmental pollutant ozone, at sufficiently high levels, is known to induce pulmonary inflammation with resultant airway obstruction in normal subjects. Eicosanoids comprise one group ofExpand
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