Corpus ID: 93763293

In vitro oxidant stress causes preferential loss of IRS proteins in rat skeletal muscle

  title={In vitro oxidant stress causes preferential loss of IRS proteins in rat skeletal muscle},
  author={Tara L. Archuleta},
  journal={The FASEB Journal},
  • Tara L. Archuleta
  • Published 2008
  • Chemistry
  • The FASEB Journal
  • Oxidative stress, the imbalance of oxidant production and the antioxidant defenses in the cell, can impair the functionality of elements of the insulin-signaling pathway that regulates glucose metabolism in skeletal muscle. In this context, the primary purpose of the present investigation was to characterize the effects of shorter-term (2 hr) and longer-term (4 hr) oxidative stress on protein expression of critical insulin signaling elements in rat skeletal muscle. Soleus muscles from insulin… CONTINUE READING

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