In vitro osteogenic differentiation of adipose-derived mesenchymal stem cell spheroids impairs their in vivo vascularization capacity inside implanted porous polyurethane scaffolds.

@article{Laschke2014InVO,
  title={In vitro osteogenic differentiation of adipose-derived mesenchymal stem cell spheroids impairs their in vivo vascularization capacity inside implanted porous polyurethane scaffolds.},
  author={Matthias W Laschke and Timo Emanuel Schank and Claudia Scheuer and Sascha Kleer and Takhirjan Shadmanov and David Eglin and Mauro Alini and Michael Dieter Menger},
  journal={Acta biomaterialia},
  year={2014},
  volume={10 10},
  pages={
          4226-35
        }
}
Undifferentiated adipose-derived mesenchymal stem cell (adMSC) spheroids are attractive vascularization units for tissue engineering. Their osteogenic differentiation further offers the possibility of directed generation of bone constructs. The aim of this study was to analyze how this differentiation affects their in vivo vascularization capacity. Green fluorescent protein (GFP)-positive adMSCs were isolated from C57BL/6-TgN(ACTB-EGFP)1Osb/J mice for the generation of undifferentiated and… CONTINUE READING
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