In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418.

@article{Donnellyroberts1996InVN,
  title={In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418.},
  author={D L Donnelly-roberts and I C Xue and Stephen Arneric and James P. Sullivan},
  journal={Brain research},
  year={1996},
  volume={719 1-2},
  pages={36-44}
}
Recent literature has shown that compounds interacting with neuronal nicotinic acetylcholine receptors (nAChRs) have the potential to be neuroprotective both in vitro and in vivo. ABT-418 is a novel ChCA that selectively stimulates discrete subtypes of the nAChRs and exhibits cognitive enhancing activity. In the present study, the neuroprotective effects of ABT-418 and (-)-nicotine, as measured by the release of lactate dehydrogenase (LDH) into the media, were investigated in a glutamate (Glu… CONTINUE READING
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