In vitro neuromuscular activity of snake venoms

@article{Hodgson2002InVN,
  title={In vitro neuromuscular activity of snake venoms},
  author={Wayne C. Hodgson and Janith Chatura Wickramaratna},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={2002},
  volume={29}
}
1. Snake venoms consist of a multitude of pharmacologically active components used for the capture of prey. Neurotoxins are particularly important in this regard, producing paralysis of skeletal muscles. These neurotoxins can be classified according to their site of action (i.e. pre‐ or post‐synaptic). 
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A deeper knowledge of alternative ways to inhibit venom toxins may provide supplemental treatments to serum therapy, and direct electric current from low voltage showed neutralizing properties against venom phospholipase A2 and metalloproteases.
[The composition, biochemical properties and toxicity of snake venoms].
TLDR
All snake venoms are grouped depending on their mode of action, and usually cause neurotransmission disorders, cardiotoxic action, hemostasis disorders, and have central nervous system and necrotic activity.
Presynaptic neurotoxins with enzymatic activities.
TLDR
This work focuses on presynaptic neurotoxins, which are very potent inhibitors of the neurotransmitter release because they are endowed with specific enzymatic activities: (1) clostridial neurotoxin with a metallo-proteolytic activity and (2).
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Neuromuscular activity of Bothrops alcatraz snake venom in chick biventer cervicis preparations.
Preliminary Results of the in Vivo and in Vitro Characterization of a Tentacle Venom Fraction from the Jellyfish Aurelia aurita
TLDR
Electrophysiological characterization demonstrated that one of these fractions potently inhibited ACh-elicited currents mediated by both vertebrate fetal and adult muscle nicotinic acetylcholine receptors (nAChR) subtypes.
Snake Venom: Any Clue for Antibiotics and CAM?
TLDR
It is shown that snake venoms are not totally unexplored sources for antibiotics and complementary and alternative medicine (CAM) and how the microorganisms can be resistant to antibiotics is shown.
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In vitro comparison of enzymatic effects among Brazilian Bothrops spp. venoms.
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