In vitro neural injury model for optimization of tissue-engineered constructs.

@article{Cullen2007InVN,
  title={In vitro neural injury model for optimization of tissue-engineered constructs.},
  author={Daniel Cullen and Sarah E Stabenfeldt and Crystal M. Simon and Ciara C. Tate and Michelle C. LaPlaca},
  journal={Journal of neuroscience research},
  year={2007},
  volume={85 16},
  pages={3642-51}
}
Stem cell transplantation is a promising approach for the treatment of traumatic brain injury, although the therapeutic benefits are limited by a high degree of donor cell death. Tissue engineering is a strategy to improve donor cell survival by providing structural and adhesive support. However, optimization prior to clinical implementation requires expensive and time-consuming in vivo studies. Accordingly, we have developed a three-dimensional (3-D) in vitro model of the injured host… CONTINUE READING
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