In vitro mutagenicity of valepotriates

@article{Hude2004InVM,
  title={In vitro mutagenicity of valepotriates},
  author={W. Hude and Michael Scheutwinkel-Reich and R. Braun and W. Dittmar},
  journal={Archives of Toxicology},
  year={2004},
  volume={56},
  pages={267-271}
}
Valepotriates are epoxide-bearing triesters of the monoterpene alcohol 4,7-dimethylcyclopenta-(c)-pyrane isolated from the roots of several Valerianacae species. They are regarded as the main tranquilizing constituents of these drugs.Although the valepotriates valtrate/isovaltrate (VAL) and dihydrovaltrate (DH-VAL) showed a strong alkylating activity against the nucleophilic agent 4-(p-nitrobenzyl)-pyridine (NBP), they were not clearly mutagenic for the strains TA98, TA100, TA1535, and TA1537… 
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