In vitro mutagenicity of valepotriates

  title={In vitro mutagenicity of valepotriates},
  author={W. Hude and Michael Scheutwinkel-Reich and R. Braun and W. Dittmar},
  journal={Archives of Toxicology},
Valepotriates are epoxide-bearing triesters of the monoterpene alcohol 4,7-dimethylcyclopenta-(c)-pyrane isolated from the roots of several Valerianacae species. They are regarded as the main tranquilizing constituents of these drugs.Although the valepotriates valtrate/isovaltrate (VAL) and dihydrovaltrate (DH-VAL) showed a strong alkylating activity against the nucleophilic agent 4-(p-nitrobenzyl)-pyridine (NBP), they were not clearly mutagenic for the strains TA98, TA100, TA1535, and TA1537… 
Potentially adverse interactions between haloperidol and valerian.
Studies on the cytological and biochemical effects of valerian in somatic and germ cells of Swiss albino mice.
Valerian-Derived Sedative Agents. I. On the Structure and Spectral Assignment of the Constituents of Valmane Using the Selective INEPT Nuclear Magnetic Resonance Technique
Using the selective INEPT NMR technique and employing a suitable polarization delay for long-range coupling, it was possible to achieve the assignment and location of the ester groups directly, without ambiguity, and without chemical modification.
A comprehensive pharmacognostic report on Valerian.
The Medicinally important herbal drug Valerian is reviewed for various taxonomical aspects including botanical authenticity, historical backgrounds, description, existing common names, medicinally important species, going through cultivation, commerce, regulation to phytochemical description, pharmacodynamics, pharmacokinetics, adverse drug reactions, toxicology, contraindications and safety aspects of valerian.
Valeriana officinalis ameliorates vacuous chewing movements induced by reserpine in rats
V. officinalis had behavioral protective effect against reserpine-induced VCMs in rats; however, the exact mechanisms that contributed to this effect have not been completely understood.
A review on genotoxic and mutagenic effects of monoterpenes
This review sketches genotoxic and mutagenic potentials of monoterpenes, which find outs some important genotoxic, mutagenic as well as non-genotoxic and non-mutagenic monoterpenes. Monoterpenes are
Valeriana officinalis (Valerian)
Ingestão da tintura de valeriana officinalis protege da discinesia orofacial induzida por reserpina em ratos
The findings demonstrate that reserpine caused a marked increase on VCMs and the co-treatment with V. officinalis was able to reduce the intensity of VCM, and the mechanisms involved in this protective activity needs to be further investigated to better understand the action of V. Officinalis.
Chemical Information Review Document for Valerian (Valeriana officinalis L.) [CAS No. 8057-49-6] and Oils
  • Biology
  • 2009
The data on the efficacy of valerian as a sleep aid are conflicting with some studies showingValerian to be an effective sleep aid while others indicating the effects to be comparable to placebo.


Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.
Four benzo-ring epoxides of the environmental carcinogen benzo(a)pyrene (BP) were tested for mutagenic and cytotoxic activity in 3 strains of Salmonella typhimurium and in Chinese hamster V79 cells.
Bacterial mutagenicity investigation of epoxides: drugs, drug metabolites, steroids and pesticides.
Mutagenic properties of allylic and alpha, beta-unsaturated compounds: consideration of alkylating mechanisms.
The alkylating activities in a systematically selected series of allyl and allylic compounds correlate well with the direct mutagenic potential as determined in the Ames test using Salmonella typhimurium TA 100 as tester strain.
The action of valepotriates on the synthesis of DNA and proteins of cultured hepatoma cells.
It is revealed that a low dose of valtrate, rapidly and extensively inhibits the synthesis of both DNA and proteins, but at double the dose of didrovaltrate.
Effect of plasma and carboxylesterase on the stability, mutagenicity, and DNA cross-linking activity of some direct-acting N-nitroso compounds.
The effects of mouse plasma, human plasma, and purified porcine liver carboxylesterase on nitrosourea, nitrosamide, and nitrosocarbamate chemical stability, mutagenicity, and DNA cross-linking
Species difference in liver microsomal and cytosolic enzymes involved in mutagenic activation of N-hydroxy-N-2-fluorenylacetamide.
Data indicate that species differ in the kinds of liver cytosolic enzymes involved in mutagenic activation of N-OH-2-FAA but not in the kind of liver microsomal enzyme involved.