In vitro mutagenicity of valepotriates

@article{Hude2004InVM,
  title={In vitro mutagenicity of valepotriates},
  author={W. Hude and M. Scheutwinkel-Reich and R. Braun and W. Dittmar},
  journal={Archives of Toxicology},
  year={2004},
  volume={56},
  pages={267-271}
}
Valepotriates are epoxide-bearing triesters of the monoterpene alcohol 4,7-dimethylcyclopenta-(c)-pyrane isolated from the roots of several Valerianacae species. They are regarded as the main tranquilizing constituents of these drugs.Although the valepotriates valtrate/isovaltrate (VAL) and dihydrovaltrate (DH-VAL) showed a strong alkylating activity against the nucleophilic agent 4-(p-nitrobenzyl)-pyridine (NBP), they were not clearly mutagenic for the strains TA98, TA100, TA1535, and TA1537… Expand
Potentially adverse interactions between haloperidol and valerian.
  • C. D. Dalla Corte, R. Fachinetto, +8 authors J. Rocha
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2008
Studies on the cytological and biochemical effects of valerian in somatic and germ cells of Swiss albino mice.
Valeriana officinalis ameliorates vacuous chewing movements induced by reserpine in rats
Valeriana officinalis (Valerian)

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