In vitro mutagenesis and SOS repair.

@article{Strauss1989InVM,
  title={In vitro mutagenesis and SOS repair.},
  author={Bernard S Strauss},
  journal={Annali dell'Istituto superiore di sanita},
  year={1989},
  volume={25 1},
  pages={177-89}
}
SOS repair in Escherichia coli (E. coli) utilizes inducible gene products to "fix" mutations in the genome. It has been supposed that an "error prone" system is induced which makes errors in the course of bypassing lesions. An alternative model has been proposed by Bridges and Woodgate which suggests that it is the elongation step rather than the insertion opposite a damaged site which is critical in SOS mutagenesis. A variety of in vitro evidence supports this more recent model. DNA… CONTINUE READING

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