In vitro modulation of prolactin binding to human mammary carcinoma cells by steroid hormones and prolactin.

@article{Simon1985InVM,
  title={In vitro modulation of prolactin binding to human mammary carcinoma cells by steroid hormones and prolactin.},
  author={Wolfgang E. Simon and Volker Pahnke and Fritz H{\"o}lzel},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1985},
  volume={60 6},
  pages={1243-9}
}
This study demonstrates the specific binding of human (h) PRL to mammary carcinoma cells of the newly established line EFM-19. Under saturating conditions, [125I]hPRL bound to these cells with high affinity (Ka = 4.3 X 10(10) M-1) and low capacity (4080 binding sites/cell). In serum-free medium, stimulation of cell proliferation by PRL was found, suggesting a biological role in the growth of human breast cancer. hPRL was more effective in binding to and promoting the growth of EFM-19 cells than… CONTINUE READING
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