In vitro models of anti-atherosclerotic effects of cardiovascular drugs.

@article{Orekhov1990InVM,
  title={In vitro models of anti-atherosclerotic effects of cardiovascular drugs.},
  author={Alexander N Orekhov},
  journal={The American journal of cardiology},
  year={1990},
  volume={66 21},
  pages={23I-28I}
}
In studies performed on cells isolated from the subendothelial intimal layer of both normal and atherosclerotic human aortas, cells from atherosclerotic lesions retained atherosclerotic properties while in primary culture, including enhanced proliferative activity and high lipid level. The content and composition of lipids in cultured cells remained unchanged for the first 10 to 12 days in culture and corresponded to the respective indices in freshly isolated cells. When added to an… CONTINUE READING