In vitro modeling of the structure–activity determinants of anthracycline cardiotoxicity

@article{Menna2006InVM,
  title={In vitro modeling of the structure–activity determinants of anthracycline cardiotoxicity},
  author={Pierantonio Menna and Giorgio Minotti and Emanuela Salvatorelli},
  journal={Cell Biology and Toxicology},
  year={2006},
  volume={23},
  pages={49-62}
}
Doxorubicin and other anthracyclines rank among the most effective anticancer drugs ever developed. Unfortunately, the clinical use of anthracyclines is limited by a dose-related life-threatening cardiotoxicity. Understanding how anthracyclines induce cardiotoxicity is essential to improve their therapeutic index or to identify analogues that retain activity while also inducing less severe cardiac damage. Here, we briefly review the prevailing hypotheses on anthracycline-induced cardiotoxicity… CONTINUE READING