In vitro model of mammary estrogen metabolism: structural and kinetic differences between catechol estrogens 2- and 4-hydroxyestradiol.

@article{Dawling2004InVM,
  title={In vitro model of mammary estrogen metabolism: structural and kinetic differences between catechol estrogens 2- and 4-hydroxyestradiol.},
  author={Sheila Dawling and David L. Hachey and Nady Roodi and Fritz F. Parl},
  journal={Chemical research in toxicology},
  year={2004},
  volume={17 9},
  pages={1258-64}
}
Estrogens and their oxidative metabolites, the catechol estrogens, have been implicated in the development of breast cancer; yet, relatively little is known about estrogen metabolism in the breast. To determine how the parent hormone, 17 beta-estradiol (E(2)), is metabolized, we used recombinant, purified phase I enzymes, cytochrome P450 (CYP) 1A1 and 1B1… CONTINUE READING