In vitro model of attachment of Giardia intestinalis trophozoites to IEC-6 cells, an intestinal cell line.

@article{McCabe1991InVM,
  title={In vitro model of attachment of Giardia intestinalis trophozoites to IEC-6 cells, an intestinal cell line.},
  author={Robert E McCabe and Guoyue Yu and Chris N. Conteas and Paul R Morrill and B McMorrow},
  journal={Antimicrobial agents and chemotherapy},
  year={1991},
  volume={35 1},
  pages={29-35}
}
Attachment of giardias to intestinal cells has been difficult to study because of a lack of a convenient in vitro model. We developed an assay for attachment of radiolabeled trophozoites to IEC-6 cells that can be done in microtiter trays. Attachment was confirmed by scanning and transmission electron microscopy. Trophozoites remained attached to the IEC-6 cells for 24 h with little evidence of damage to the IEC-6 cells. Preincubation of trophozoites with cytochalasins A, B, and D reduced… CONTINUE READING

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