In vitro model for the nuclear transport of the hepadnavirus genome.

@article{Kann1997InVM,
  title={In vitro model for the nuclear transport of the hepadnavirus genome.},
  author={Michael Kann and Anja Bischof and Wolfram H. Gerlich},
  journal={Journal of virology},
  year={1997},
  volume={71 2},
  pages={1310-6}
}
Hepadnaviruses contain a DNA genome, but they replicate via an RNA intermediate, synthesized by the cellular RNA polymerase II in the nucleus of the infected cell. Thus, nuclear transport of the viral DNA is required in the viral life cycle. Protein-free DNA is only poorly imported into the nucleus, so one or more of the viral proteins must be involved in the transport of the viral genome. In order to identify these viral proteins, we purified woodchuck hepadnavirus (WHV) core particles from… CONTINUE READING
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