In vitro microscopic imaging of enhanced thrombolysis with 120-kHz ultrasound in a human clot model.

@article{Cheng2005InVM,
  title={In vitro microscopic imaging of enhanced thrombolysis with 120-kHz ultrasound in a human clot model.},
  author={Jason Chia-Sheng Cheng and George J. Shaw and Christy K. Holland},
  journal={Acoustics research letters online : ARLO},
  year={2005},
  volume={6 1},
  pages={
          25-29
        }
}
Substantial enhancement of recombinant tissue plasminogen activator (rt-PA) thrombolysis can be achieved with ultrasound, suggesting its use as an adjunctive treatment in thrombolytic therapy for stroke. A microscopic visualization method was used to measure the lysis of human whole-blood clots treated with human fresh frozen plasma (HFFP), rt-PA, and 120-kHz ultrasound for 30 min at T = 37 ° C. The clot-plasma interface was imaged using an inverted optical microscope and the thrombolytic front… CONTINUE READING
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