In vitro micromass teratogen test: Results from a blind trial of 25 compounds.

@article{Uphill1990InVM,
  title={In vitro micromass teratogen test: Results from a blind trial of 25 compounds.},
  author={P. F. Uphill and S. DeC. Wilkins and Judith A. Allen},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={1990},
  volume={4 4-5},
  pages={
          623-6
        }
}
The results obtained by Huntingdon Research Centre participating in a blind trial of the micromass assay for the prediction of teratogenic potential are presented. Twenty-five coded compounds were tested without S-9 mix using a pre-agreed protocol; three compounds were later tested with S-9. The data were assessed for sensitivity, specificity and accuracy using three separate sets of criteria based on either concentration (the <500 mug/ml rule (i) and the <50 mug/ml rule (ii)) or specific… CONTINUE READING
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