In vitro methods for confirming reduced susceptibility to cefuroxime amongHaemophilus influenzae isolates

Abstract

possible to ascertain which of the two possibilities was responsible. It has been discussed that reactivation from the trigeminal ganglion, which allows travel of virions down the sensory nerve to epithelial cells, can occur three or more days after stimulation (5). Thus, if surgery was the stimulus that induced reactivation, the timing of the meningitis after surgery (15 days) was not in accordance with this hypothesis, even if the exact delay for an acute episode of HSV-1 meningitis is not known. The second possible cause is peroperatory diffusion of HSV-1 from the oral area to the CSF, which may have happened if silent reactivation occurred prior to surgery. Since no oral secretion sample was obtained prior to surgery, this theory cannot be proven, so the exact cause of this infection remains unknown.

DOI: 10.1007/BF01695645

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Cite this paper

@article{Macgowan1997InVM, title={In vitro methods for confirming reduced susceptibility to cefuroxime amongHaemophilus influenzae isolates}, author={Alasdair P Macgowan and Mandy Wootton and Peter A James and Karen E. Bowker and Helene A Holt and David S Reeves}, journal={European Journal of Clinical Microbiology and Infectious Diseases}, year={1997}, volume={16}, pages={328-329} }