Corpus ID: 27994528

In vitro metabolism using rainbow trout liver S9 Summary report of the HESI Bioaccumulation Committee

@inproceedings{Johanning2012InVM,
  title={In vitro metabolism using rainbow trout liver S9 Summary report of the HESI Bioaccumulation Committee},
  author={K. Johanning and G. Hancock and B. Escher and A. Adekola and M. Bernhard and C. Cowan-Ellsberry and J. Domoradzki and S. Dyer and C. Eickhoff and S. Erhardt and Patrick Fitzsimmons and M. Halder and J. Nichols and Sibylle and A. Sharpe and H. Segner and I. Schultz and Michelle Embry},
  year={2012}
}
  • K. Johanning, G. Hancock, +15 authors Michelle Embry
  • Published 2012
  • Standard methods to assess bioaccumulation, such as QSARs, computer modeling, and the in vivo OECD 305 Test Guideline do not incorporate estimates of metabolism and are not valid for many chemical classes. In order to improve the in vitro assessment of bioaccumulation/bioconcentration assessment and enable concerted evaluations of thousands of commercial substances in a scientifically correct, timely and cost effective manner, this study was undertaken to examine and pre-validate the utility of… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 11 REFERENCES
    Approach for extrapolating in vitro metabolism data to refine bioconcentration factor estimates.
    • 95
    A database of fish biotransformation rates for organic chemicals.
    • 100
    Estimating metabolic biotransformation rates in fish from laboratory data.
    • 113
    Effect of BDE-47 on hepatic drug metabolizing enzymes in isogenic trout
    • 2007