In vitro metabolism using rainbow trout liver S 9 Summary report of the HESI Bioaccumulation Committee

@inproceedings{Johanning2012InVM,
  title={In vitro metabolism using rainbow trout liver S 9 Summary report of the HESI Bioaccumulation Committee},
  author={Karla M Johanning and Gregg Hancock and Beate I Escher and Adebayo Adekola and M. Bernhard and Christina E Cowan-Ellsberry and Jean Y Domoradzki and Scott Dyer and Curtis V Eickhoff and Susan Erhardt and Patrick Fitzsimmons and Marlies Halder and John Nichols and Sibylle Rutishauser and Alan D. Sharpe and Helmut Segner and Irvin R. Schultz and M R Embry},
  year={2012}
}
Standard methods to assess bioaccumulation, such as QSARs, computer modeling, and the in vivo OECD 305 Test Guideline do not incorporate estimates of metabolism and are not valid for many chemical classes. In order to improve the in vitro assessment of bioaccumulation/bioconcentration assessment and enable concerted evaluations of thousands of commercial substances in a scientifically correct, timely and cost effective manner, this study was undertaken to examine and pre-validate the utility of… CONTINUE READING